Show simple item record

dc.contributor.authorMason, Shayne
dc.date.accessioned2017-03-13T09:19:45Z
dc.date.available2017-03-13T09:19:45Z
dc.date.issued2017
dc.identifier.citationMason, S. 2017. Lactate shuttles in neuroenergetics: homeostasis, allostasis and beyond. Frontiers in neuroscience, 11: Article no 43. [https://doi.org/10.3389/fnins.2017.00043]en_US
dc.identifier.issn1662-4548
dc.identifier.issn1662-453X (Online)
dc.identifier.urihttp://hdl.handle.net/10394/20787
dc.identifier.urihttps://doi.org/10.3389/fnins.2017.00043
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fnins.2017.00043/full
dc.description.abstractUnderstanding brain energy metabolism—neuroenergetics—is becoming increasingly important as it can be identified repeatedly as the source of neurological perturbations. Within the scientific community we are seeing a shift in paradigms from the traditional neurocentric view to that of a more dynamic, integrated one where astrocytes are no longer considered as being just supportive, and activated microglia have a profound influence. Lactate is emerging as the “good guy,” contrasting its classical “bad guy” position in the now superseded medical literature. This review begins with the evolution of the concept of “lactate shuttles”; goes on to the recent shift in ideas regarding normal neuroenergetics (homeostasis)—specifically, the astrocyte–neuron lactate shuttle; and progresses to covering the metabolic implications whereby homeostasis is lost—a state of allostasis, and the function of microglia. The role of lactate, as a substrate and shuttle, is reviewed in light of allostatic stress, and beyond—in an acute state of allostatic stress in terms of physical brain trauma, and reflected upon with respect to persistent stress as allostatic overload—neurodegenerative diseases. Finally, the recently proposed astrocyte–microglia lactate shuttle is discussed in terms of chronic neuroinflammatory infectious diseases, using tuberculous meningitis as an example. The novelty extended by this review is that the directionality of lactate, as shuttles in the brain, in neuropathophysiological states is emerging as crucial in neuroenergeticsen_US
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.subjectNeuroenergeticsen_US
dc.subjectLactateen_US
dc.subjectAstrocyte-neuron lactate shuttle (ANLS)en_US
dc.subjectAstrocyte-microglia lactate shuttle (AMLS)en_US
dc.subjectNeuropathologyen_US
dc.subjectTraumatic brain injury (TBI)en_US
dc.subjectNeurodegenerative diseaseen_US
dc.subjectInfectious neuroinflammatory diseaseen_US
dc.titleLactate shuttles in neuroenergetics: homeostasis, allostasis and beyonden_US
dc.typeArticleen_US
dc.contributor.researchID21487855 - Mason, Shayne William


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record