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dc.contributor.authorVon Kanel, Roland
dc.contributor.authorMalan, Nicolaas Theodor
dc.contributor.authorHamer, Mark
dc.contributor.authorMalan, Leoné
dc.identifier.citationVon, K.R. et al 2015. Comparison of telomere length in Black and White teachers from South Africa: the sympathetic activity and ambulatory blood pressure in Africans study. Psychosomatic medicine, 77(1):26-32. []en_US
dc.identifier.issn1534–7796 (Online)
dc.description.abstractObjective: Telomere length is a marker of biological aging that has been linked to cardiovascular disease risk. The black South African population is witnessing a tremendous increase in the prevalence of cardiovascular disease, part of which might be explained through urbanization. We compared telomere length between black South Africans and white South Africans and examined which biological and psychosocial variables played a role in ethnic difference in telomere length. Methods: We measured leukocyte telomere length in 161 black South African teachers and 180 white South African teachers aged 23 to 66 years without a history of atherothrombotic vascular disease. Age, sex, years having lived in the area, human immunodeficiency virus (HIV) infection, hypertension, body mass index, dyslipidemia, hemoglobin A1c, C–reactive protein, smoking, physical activity, alcohol abuse, depressive symptoms, psychological distress, and work" "stress were considered as covariates. Results: Black participants had shorter (median, interquartile range) relative telomere length (0.79, 0.70Y0.95) than did white participants (1.06, 0.87Y1.21; p G .001), and this difference changed very little after adjusting for covariates. In fully adjusted models, age (p G .001), male sex (p = .011), and HIV positive status (p = .023) were associated with shorter telomere length. Ethnicity did not significantly interact with any covariates in determining telomere length, including psychosocial characteristics." "Conclusions: Black South Africans showed markedly shorter telomeres than did white South African counterparts. Age, male sex, and HIVstatuswere associatedwith shorter telomere length.No interactions between ethnicity and biomedical or psychosocial factorswere found. Ethnic difference in telomere length might primarily be explained by genetic factors. Key words: cardiovascular disease, ethnicity, genetics," "psychological stress, telomere.en_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectethnicity, geneticsen_US
dc.subjectpsychological stressen_US
dc.subjectbody mass index (BMI)en_US
dc.subjectblood pressure (BP)en_US
dc.subjectCRP (C-reactive protein)en_US
dc.subjectCVD (cardiovascular disease)en_US
dc.subjectDNA (deoxyribonucleic acid)en_US
dc.subject[gamma]-GT = [gamma]-glutamyltransferaseen_US
dc.subjectHbA1c = glycosylated hemoglobin A1cen_US
dc.subjectHDL-C = high-density lipoprotein cholesterolen_US
dc.subjectHIV (human immunodeficiency virus)en_US
dc.subjectQ-PCR (quantitative real-time polymerase chain reaction)en_US
dc.subjectSABPA (Sympathetic Activity and Ambulatory Blood Pressure in Africans)en_US
dc.subjectSES (socioeconomic status)en_US
dc.subjectT-C (total cholesterol)en_US
dc.titleComparison of Telomere Length in Black and White Teachers From South Africa: the Sympathetic Activity and Ambulatory Blood Pressure in Africans Studyen_US
dc.contributor.researchID22684808 - Hamer, Mark
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor

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