Browsing Faculty of Natural and Agricultural Sciences by Subject "Metallothionein"

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    • The involvement of metallothioneins in mitochondrial function and disease 

      Lindeque, J.Z.; Levanets, O.; Louw, R.; Van der Westhuizen, F.H. (Bentham Science, 2010)
      Mitochondrial oxidative phosphorylation deficiency is accompanied by various down-stream, adaptive responses which play a key role in the varied phenotypes observed when mitochondrial dysfunction occurs. These responses ...

    • Metallothionein 1 overexpression does not protect against mitochondrial disease pathology in Ndufs4 knockout mice 

      Miller, Hayley Christy; Louw, Roan; Mereis, Michelle; Venter, Gerda; Boshoff, John-Drew; Mienie, Liesel; Van Reenen, Mari; Venter, Marianne; Lindeque, Jeremie Zander; Van der Westhuizen, Francois Hendrikus (Springer, 2021)
      Mitochondrial diseases (MD), such as Leigh syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known cure and limited treatment options. Based on their neuroprotective effects ...