Browsing Faculty of Natural and Agricultural Sciences by Author "10060871 - Malan, Leoné"
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
The association between seven-day objectively measured habitual physical activity and 24 h ambulatory blood pressure: the SABPA study
Hamer, M.; Bruwer, E.J.; De Ridder, J.H.; Swanepoel, M.; Cockeran, M.; Malan, L. (Springer Nature, 2017)Few studies have examined objective physical activity in relation to 24 h ambulatory blood pressure (BP). We aimed to assess the association of 7-day objectively measured habitual physical activity with ambulatory BP in a ... -
Association of waist circumference with perception of own health in urban African males and females: the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study
Botha, J.; Malan, L.; Potgieter, J.C.; Steyn, H.S.; De Ridder, J.H. (Health & Medical Publishing Group (JEMDSA), 2012)Background: Current waist circumference (WC) cut-points of the Joint Statement Consensus (JSC) (male ≥ 94 cm, female ≥ 80 cm) were compared with a recently proposed WC cut-point (RPWC) (male ≥ 90 cm, female ≥ 98 cm). In ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Baroreceptor sensitivity, cardiovascular responses and ECG left ventricular hypertrophy in men: the SABPA study
Van Lill, Lisa; Malan, Leoné; Van Rooyen, Johannes; Steyn, Faans; Reimann, Manja; Ziemssen, Tjalf (Taylor & Francis, 2011)Aim. Research has shown a significant relationship between hypertension and attenuated baroreceptor sensitivity (BRS), which in turn reflects alterations of autonomic control of the cardiovascular system. The objective of ... -
Blood glutathione and subclinical atherosclerosis in African men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Szabolcs, Péter; Fourie, Carla M.T.; Van der Westhuizen, Francois H.; Louw, Roan; Botha, Cindy A.; Malan, Leoné (Oxford Univ Press, 2009)Background: Sub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities ... -
Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point: the SABPA study
Malan, Leoné; Hamer, Mark; Von Känel, Roland; Steyn, Hendrik S.; Malan, Nicolaas T. (Elsevier, 2017)Background Sympatho-adrenal responses are activated as an innate defense coping (DefS) mechanism during emotional stress. Whether these sympatho-adrenal responses drive cardiac troponin T (cTnT) increases are unknown. ... -
Cohort profile: sympathetic activity and ambulatory blood pressure in Africans (SABPA) prospective cohort study
Malan, Leoné; Hamer, Mark; Steyn, Hendrik S.; Malan, Nicolaas T.; Frasure-Smith, Nancy (Oxford Univ Press, 2015)Adapting to an over–demanding stressful urban environment may exhaust the psychophysiological resources to cope with these demands, and lead to sympathetic nervous system dysfunction. The evidence that an urban–dwelling ... -
The contribution of the C-824T tyrosine hydroxylase polymorphism to the prevalence of hypertension in a South African cohort: the SABPA study
Van Deventer, Cindy A.; Louw, Roan; Van der Westhuizen, Francois H.; Vorster, Chris B.; Malan, Leoné (Taylor & Francis, 2013)The C-824T single nucleotide polymorphism in the promoter region of the tyrosine hydroxylase gene has been associated with hypertension. It is well documented that African South Africans exhibit a higher prevalence of ... -
Coping facilitated troponin T increases and hypo-responsivity in the copeptin-HPA-axis during acute mental stress in a black cohort: the SABPA study
Myburgh, Catharina Elizabeth; Malan, Leoné; Möller, Marisa; Steyn, Faans; Malan, Nicolaas Theodor (Elsevier, 2019)Background Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an ... -
Cortisol: brain-derived neurotrophic factor ratio associated with silent ischaemia in a black male cohort: the SABPA study
Schutte, Christiaan E.; Malan, Leoné; Scheepers, Jacobus D.; Oosthuizen, Woudri; Cockeran, Maricke; Malan, Nicolaas T. (SASA, 2016)Aim: Emotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore ... -
Cultural coping as a risk for depression and hypertension: the SABPA prospective study
Le Roux, S.; Lotter, G.A.; Steyn, H.S.; Malan, L. (Clinics Cardive, 2018)Objectives: In past studies, a lack of social support has been associated with cardiovascular disease (CVD) risk, particularly in black Africans. However, whether or not coping strategies have beneficial effects on blood ... -
Defensive active coping facilitates chronic hyperglycaemia and endothelial dysfunction in African men: the SABPA study
Malan, L.; Hamer, M.; Steyn, H.S.; Schutte, R.; Smith, W.; Van Rooyen, J.M.; Fourie, C.M.T.; Malan, N.T. (Elsevier, 2013)Background: Dissociation between behavioural defensive active coping (AC) control albeit physiological “loss of control” responses was associated with silent ischaemia and structural wall abnormalities in African men. Whether ... -
Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study
Malan, Leoné; De Kock, Andrea; Hamer, Mark; Cockeran, Marike; Malan, Nicolaas Theodor (Taylor & Francis, 2018)Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It ... -
Determining the waist circumference cut off which best predicts the metabolic syndrome components in urban Africans: the SABPA study
Prinsloo, J.; Malan, L.; De Ridder, J.H.; Potgieter, J.C.; Steyn, H.S. (Thieme Publishing, 2011)Various studies have shown that the relationship between waist circumference (WC) and abdominal obesity is age, gender as well as ethnicity-dependent. WC criteria for Sub Saharan Africans have not been defined by the ... -
Determining the waist circumference cut off which best predicts the metabolic syndrome components in urban Africans: the SABPA study
Malan, Leoné; Potgieter, Johannes Cornelis; Steyn, Hendrik Stefanus; Prinsloo, J.; De Ridder, Johannes Hendrik (Thieme Publications, 2011)Various studies have shown that the relationship between waist circumference (WC) and abdominal obesity is age, gender as well as ethnicity-dependent. WC criteria for Sub Saharan Africans have not been defined by the ... -
Ethnic disparity in defensive coping endothelial responses: the SABPA study
Scheepers, Jacobus De Wet; Malan, Leoné; De Kock, Andrea; Malan, Nicolaas Theodor; Cockeran, Marike; Von Känel, Roland (Elsevier, 2015)Objectives: Defensive coping (DefS) in Blacks has been associated with greater cardiovascular risk than in their White counterparts. We examined associations between endothelial function mental stress responses and markers ... -
Fibrosis and coronary perfusion: a cardiovascular disease risk in an African male cohort: the SABPA study
Jansen van Vuren, Esmé; Malan, Leoné; Cockeran, Marike; Scheepers, Jacobus D.; Oosthuizen, Woudri; Malan, Nicolaas T. (Taylor & Francis, 2016)Low-grade inflammation has been correlated with risk factors of cardiovascular diseases (CVD). Whether the pro-inflammatory and thrombotic ratio (fibrosis) may contribute to CVD is not known. We therefore aimed to assess ... -
Genetic polymorphisms of beta(2)- and beta(3)- adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
Van Rooyen, J.M.; Pretorius, P.J.; Britz, M.; Huisman, H.W.; Schutte, A.E.; Towers, G.W.; Olckers, A.; Malan, N.T.; Malan, L.; Schutte, R. (Thieme, 2008)Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity ... -
Hypercoagulation and hyperkinetic blood pressure indicative of physiological loss-of-control despite behavioural control in Africans: the SABPA study
Scheepers, Jacobus De Wet; Malan, Leoné; De Kock, Andrea; Malan, Nicolaas Theodor; Cockeran, Marike; Von Känel, Roland (Taylor & Francis, 2016)Objectives: A dissociation between behavioural (in-control) and physiological parameters (indicating loss-of-control) is associated with cardiovascular risk in defensive coping (DefS) Africans. We evaluated relationships ...