Browsing Faculty of Natural and Agricultural Sciences by Subject "Oxidative stress"
Now showing items 1-10 of 14
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A 3-methylcrotonyl-CoA carboxylase deficient human skin fibroblast transcriptome reveals underlying mitochondrial dysfunction and oxidative stress
(Elsevier, 2016)Isolated 3-methylcrotonyl-CoA carboxylase (MCC) deficiency is an autosomal recessive inherited metabolic disease of leucine catabolism with a highly variable phenotype. Apart from extensive mutation analyses of the MCCC1 ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
(Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Baseline bio-accumulation concentrations and resulting oxidative stress in Synodontis zambezensis after an acute laboratory exposure to 4,4′-DDT
(Elsevier, 2019)The use of 1,1′-(2,2,2-Trichloro-1,1-ethanediyl)bis(4-chlorobenzene) (DDT) as a pesticide for the control of insects vectors responsible for the spread of many life threatening diseases was officially banned in 1972 by the ... -
Bioaccumulation and metal-associated biomarker responses in a freshwater mussel, Dreissena polymorpha, following short-term platinum exposure
(Elsevier, 2019)Due to the increasing presence of platinum (Pt) in the environment, the caveat arises to identify its toxic potential in species at risk of being exposed – especially those found in aquatic environments where pollutants ... -
Effects of exercise on alterations in redox homeostasis in elite male and female endurance athletes using a clinical point-of-care test
(Canadian Science Publishing, 2016)Exercise causes alterations in redox homeostasis (ARH). Measuring ARH in elite athletes may aid in the identification of training tolerance, fatigued states, and underperformance. To the best of our knowledge, no studies ... -
Exploring the link between serum peroxides and angiogenesis in a bi-ethnic population from South Africa: the SAfrEIC study
(Elsevier, 2013)Background: Reactive oxygen species (ROS) play a fundamental role in angiogenesis, and in turn, angiogenic growth factors also affect ROS. Angiogenesis and ROS are intricately involved in vascular deterioration. Since ... -
Hybrid compounds from thiosemicarbazone and triazole as antidiabetic agents and their antioxidant potentials
(Allied Academies, 2017)Diabetes mellitus is a metabolic disease that threatens and reduces the quality of life. Eight hybrids (1ah) of thiosemicarbozone and triazole were screened for their effects on genes related to type 2 diabetes as well as ... -
Implementing a new variant load model to investigate the role of mtDNA in oxidative stress and inflammation in a bi-ethnic cohort: the SABPA study
(Taylor & Francis, 2019)Mitochondrial DNA (mtDNA) variation has been implicated in several common complex and degenerative diseases, including cardiovascular disease. Inflammation is seen as part of many of these conditions. Mitochondria feature ... -
Innovative drinking water treatment techniques reduce the disinfection-induced oxidative stress and genotoxic activity
(Elsevier, 2019)Disinfection of drinking water using chlorine can lead to the formation of genotoxic by-products when chlorine reacts with natural organic matter (NOM). A vast number of such disinfection by-products (DBPs) have been ... -
Iron and a mixture of DHA and EPA supplementation, alone and in combination, affect bioactive lipid signalling and morbidity of iron deficient South African school children in a two-by-two randomised controlled trial
(Elsevier Sci Ltd, 2016)We recently reported that iron supplementation increased respiratory morbidity in iron deficient South African children. This increase, however, was attenuated when iron was provided in combination with a mixture of DHA/EPA. ...