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Procoagulant reactivity to laboratory acute mental stress in Africans and Caucasians, and its relation to depressive symptoms: the SABPA study
(Thieme, 2013)
The risk of cardiovascular disease is dramatically increasing in Africans (black). The prothrombotic stress response contributes to atherothrombotic disease and is modulated by depressive symptoms. We examined coagulation ...
Novel monoamine oxidase inhibitors: a patent review (2012-2014)
(Taylor & Francis, 2015)
Introduction: Monoamine oxidase (MAO) inhibitors, despite the initial pharmacological interest, are used in clinic for their antidepressant effect and in the management of Parkinson symptoms, due to the established ...
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study
(Elsevier, 2016)
Background
Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear.
Objectives ...
Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression
(Elsevier, 2015)
Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alterations in monoaminergic neurotransmission, including noradrenergic, have been implicated in the etiology of depression. ...
The long-term effects of methamphetamine exposure during pre-adolescence on depressive-like behaviour in a genetic animal model of depression
(Springer, 2016)
Methamphetamine (METH) is a psychostimulant and drug of abuse, commonly used early in life, including in childhood and adolescence. Adverse effects include psychosis, anxiety and mood disorders, as well as increased risk ...
Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour
(Cambridge Univ Press, 2015)
Objective: Gut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural ...
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies
(Elsevier, 2014)
Although there are clinical trials and in vivo studies in literature regarding the anxiolytic and antidepressant
activities of the components of Crocus sativus L., their effects on the human monoamine oxidases
(hMAO-A ...
Cultural coping as a risk for depression and hypertension: the SABPA prospective study
(Clinics Cardive, 2018)
Objectives: In past studies, a lack of social support has been associated with cardiovascular disease (CVD) risk, particularly in black Africans. However, whether or not coping strategies have beneficial effects on blood ...
Animal models of major depressive disorder and the implications for drug discovery and development
(Taylor & Francis, 2019)
Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is ...
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)
Depressive disorders represent a significant health concern as they are associated with high social and
physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective
treatment ...