Search
Now showing items 1-10 of 16
S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression
(Oxford Univ Press, 2017)
Background:
The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In ...
Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity
(Society for Neuroscience, 2015)
Neuropeptide S (NPS) has generated substantial interest due to its anxiolytic and fear-attenuating effects in rodents, while a corresponding
receptor polymorphism associated with increased NPS receptor (NPSR1) surface ...
Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)
Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ...
Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium
(Oxford Univ Press, 2015)
Background: Telomeres are protective DNA-protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Shortening of the blood leukocyte telomeres is associated with aging, several chronic ...
A gene-environment study of cytoglobin in the human and rat hippocampus
(PLoS, 2013)
Background: Cytoglobin (Cygb) was discovered a decade ago as the fourth vertebrate heme-globin. The function of Cygb is
still unknown, but accumulating evidence from in vitro studies point to a putative role in scavenging ...
MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro
(Oxford Univ Press, 2016)
Background:
MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the ...
A preclinical study of casein glycomacropeptide as a dietary intervention for acute mania
(Oxford Univ Press, 2018)
Background
Casein glycomacropeptide is a peptide that lacks phenylalanine, tyrosine, and tryptophan. This profile may enable it to deplete phenylalanine, tyrosine, and tryptophan, and subsequently the synthesis of dopamine ...
The current development of CNS drug research
(Oxford Univ Press, 2013)
In the past few years, several high profiled pharmaceutical companies have decided to shut down major
research activities within the central nervous system (CNS) area. For example, in December 2011
Novartis announced ...
Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression
(Cambridge Univ Press, 2019)
Objectives:
Treatment-resistance to antidepressants is a major problem in the pharmacotherapy of major depressive disorder (MDD). Unfortunately, only a few animal models are suitable for studying treatment-resistant ...
Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure
(Cambridge Univ Press, 2017)
Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects ...