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2-Aminopyrimidines as dual adenosine A1/A2A antagonists
(Elsevier, 2015)
In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this ...
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B
(Elsevier, 2012)
It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on ...
Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists
(Elsevier, 2016)
A novel series of carbamate substituted 2-amino-4,6-diphenylpyrimidines was evaluated as potential dual adenosine A1 and A2A receptor antagonists. The majority of the synthesised compounds exhibited promising dual affinities, ...