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Is major depressive disorder a metabolic encephalopathy?
(Wiley, 2008)
Metabolic encephalopathy is an acute disturbance in cellular metabolism in the brain evoked by conditions of hypoxia, hypoglycaemia, oxidative stress and/or inflammation. It usually develops acutely or subacutely and is ...
Immediate and long-term antidepressive-like effects of pre-pubertal escitalopram and omega-3 supplementation combination in young adult stress-sensitive rats
(Elsevier, 2018)
Major depressive disorder (MDD) affects a significant number of children and adolescents, yet treatment options for this population remain very limited. Escitalopram (ESC) is one of only two antidepressants approved as ...
Methylene blue and its analogues as antidepressant compounds
(Springer, 2017)
Methylene Blue (MB) is considered to have diverse medical applications and is a well-described treatment for methemoglobinemias and ifosfamide-induced encephalopathy. In recent years the focus has shifted to MB as an ...
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
(Elsevier, 2009)
Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ...
A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression
(Elsevier, 2011)
Major depressive disorder (MDD) and diabetes mellitus type II (T2DM) are two of the major health challenges of our time. It has been shown that MDD and T2DM are highly co-morbid, and recent work has proposed a bi-directional ...
Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function
(Elsevier, 2011)
Depressive symptoms have been consistently associated with sub-clinical atherosclerosis and future risk of coronary heart disease events. However, the pathways linking depression and coronary atherosclerosis are poorly ...
Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences
(Springer, 2011)
Ozone (O3) (CAS 10028-15-6) is a major air industrial pollutant and is well known for its very strong oxidative actions which affords the molecule its useful antimicrobial and deodorizing properties, but also its potential ...
Neurochemical differences in two rat strains exposed to social isolation rearing
(Cambridge Univ Press, 2012)
Objective: Isolation rearing of rats provides a non-pharmacological method of inducing behavioural changes in rodents that resemble schizophrenia or depression. Nevertheless, results are variable within different strains. ...
An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats
(Elsevier, 2011)
Although it is well established that cyclic adenosine monophosphate (cAMP) signalling via cAMPdependent protein kinase (PKA)within neurons plays an important role in depression and antidepressant treatment, the importance ...
Effect of chronic N-acetyl cystine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum
(Springer, 2008)
Antioxidants have possible therapeutic value in neurodegenerative disorders, although they may have pro-oxidant effects under certain conditions. Glutathione (GSH) is a key free radical scavenger. N-acetylcysteine (NAC) ...