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Now showing items 11-20 of 208
The Khutsong housing project and power relationships: an application of Lukes’ three dimensions of power
(Taylor & Francis, 2020)
This article critically examines power relationships amongst actors in a local housing development project in the Khutsong township in South Africa. For this purpose, actors’ interpretations and actions of their project ...
Cardiovascular proteomics
(Elsevier, 2020)
Cardiovascular diseases are the major cause of morbidity and mortality worldwide. They develop over long periods of time, and are typically caused by multiple factors, and interaction with the environment. Proteomics allows ...
The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
(MDPI, 2020)
The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ...
Anti-melanoma activities of artemisone and prenylated amino-artemisinins in combination with known anticancer drugs
(Frontiers Media, 2020)
The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to skin cancer. Breakthroughs in chemotherapy have been achieved in certain cases, though only marginal advances ...
Mechanical and physical behavior of fibrin clot formation and lysis in combined oral contraceptive users
(Cambridge Univ Press, 2020)
Combined oral contraceptives (COCs) are commonly prescribed and increase the risk of venous thromboembolism (VTE). We have previously found that two COCs, both containing drospirenone (DRSP) and ethinyl estradiol (EE), ...
In vivo evaluation of acute intravenous toxicity of a [Ga-68]Ga-PSMA-11-microemulsion
(Elsevier, 2020)
Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated ...
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
(Springer Nature, 2020)
Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative ...
Methylene blue analogues: in vitro antimicrobial minimum inhibitory concentrations and in silico pharmacophore modelling
(Elsevier, 2020)
It has been shown that methylene blue has antimicrobial properties although few studies have determined its minimum inhibitory concentration (MIC), which is the gold standard used to measure antimicrobial activity. The ...
COVID-19 across Africa: epidemiologic heterogeneity and necessity of contextually relevant transmission models and intervention strategies
(American College of Physicians, 2020)
Coronavirus disease 2019 (COVID-19) has rapidly emerged as a global public health threat with epicenters in regions of China, parts of Europe, and larger urban centers across North America (1). By comparison, population-level ...
Metronidazole-conjugates: a comprehensive review of recent developments towards synthesis and medicinal perspective
(Elsevier, 2020)
Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry due to their numerous biological activities. Moreover, many clinical candidates based on this chemical core have been reported to be ...