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Inhibitory effects of novel ciprofloxacin derivatives on the growth of four Babesia species and Theileria equi
(Springer, 2020)
The problems of parasite resistance, as well as the toxic residues to most of the commercially available antipiroplasmic drugs severely weaken their effective, curative, and environmental safe employment. Therefore, it is ...
Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids
(Springer, 2020)
Infectious diseases such as tuberculosis and leishmaniasis are leading causes of human death. One of the major factors contributing to the poor control of these diseases is primarily the reduced effectiveness of the existing ...
Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues
(Elsevier, 2020)
The emergence of drug-resistant tuberculosis (DR-TB) as well as the requirement for long, expensive and toxic drug regimens impede efforts to control and eliminate TB. Therefore, there’s a need for effective and affordable ...
Recent advances in the synthesis and development of nitroaromatics as anti-infective drugs
(Bentham Science, 2020)
Infectious diseases commonly occur in tropical and sub-tropical countries. The pathogens of such diseases are able to multiply in human hosts, warranting their continual survival. Infections that are commonplace include ...
Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives
(Wiley, 2020)
Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically ...
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes
(Elsevier, 2020)
Leishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but ...
An update on derivatisation and repurposing of clinical nitrofuran drugs
(Elsevier, 2019)
5-nitrofurans (NFs) have been in clinical use for over 60 years. These affordable drugs are used for the treatment of a broad spectrum of diseases ranging from urinary tract infections to cancer. The anti-pathogenic effect ...
Synthesis and antimycobacterial activity of disubstituted benzyltriazoles
(Springer, 2019)
The increasing prevalence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the ...
Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
(Wiley, 2019)
Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ...
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
(Elsevier, 2012)
Series of bisquinolines 4e15 and bispyrrolo[1,2a]quinoxalines 16e20 containing various polyamine
linkers were synthesized. The aqueous solubility and distribution coefficient were experimentally
determined. The compounds ...