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The interactions of caffeine with monoamine oxidase
(Elsevier, 2013)
Aims: Caffeine has been used as a scaffold for the design of inhibitors of monoamine oxidase (MAO) A and B.
Substitution at the C8 position with a variety of moieties yields structures with high MAO inhibition ...
Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase
(Wiley, 2016)
Previous reports have documented that 1,4-naphtho-
quinones act as inhibitors of the monoamine oxidase
(MAO) enzymes. In particular, fractionation of the
extracts of cured tobacco leafs has led to the charac-
terization ...
The synthesis and evaluation of C7-substituted α-tetralone derivatives as inhibitors of monoamine oxidase
(Wiley, 2015)
Based on a previous report that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is a promising scaffold for the design of highly potent inhibitors of the enzyme, monoamine oxidase, the present study investigates the monoamine ...
Inhibition of monoamine oxidase by selected phenylalkylcaffeine analogues
(Wiley, 2014)
Objectives Caffeine represents a useful scaffold for the design of monoamine
oxidase (MAO) type B inhibitors. Specifically, substitution on the C8 position
yields structures which are high-potency MAO-B inhibitors. To ...
Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase
(Springer, 2019)
Based on reports that chromone compounds are good potency inhibitors of monoamine oxidase (MAO), the present study evaluates the effect of substitution with flexible side chains on the 3 position on MAO inhibition potency. ...
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
(Elsevier, 2012)
A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...