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Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
(Elsevier, 2013)
Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory
abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine
release . N-acetyl cysteine ...
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)
Schizophrenia is causally associated with early-life
environmental stress, implicating oxidative stress in its pathophysiology.
N-acetyl cysteine (NAC), a glutathione precursor
and antioxidant, is emerging as a useful ...
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
(Elsevier, 2012)
Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium
requires further study. Altered tryptophan metabolism has been described in schizophrenia,
possibly linked to ...
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
(Elsevier, 2011)
Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR ...