Now showing items 1-6 of 6
The potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases + Erratum
Recently, research into the development of new antimicrobial agents has been driven by the increase in resistance to traditional antibiotics and Emerging Infectious Diseases. Antimicrobial peptides (AMPs) are promising ...
Trends in malaria admissions at the Mbakong Health Centre of the North West Region of Cameroon: a retrospective study
(BioMed Central, 2014)
Background: Malaria is the leading cause of death worldwide. It is urgent to assess the impact of interventions and scaled-up control efforts. Despite reported reduction in malaria prevalence in Africa, the trends in ...
Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
(BioMed Central, 2013)
Background: Because Plasmodium falciparum displays increase tolerance against the recommended artemisinin combination therapies (ACT), new classes of anti-malarial drugs are urgently required. Previously synthesized ar ...
Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies-activities against blood stage P. falciparum including PfKI3 C580Y mutants and liver stage P. berghei parasites
We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives ...
Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin
Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ...
Anti-trypanosomal and antimalarial properties of tetralone derivatives and structurally related benzocycloalkanones
Background and objectives: Sleeping sickness and malaria alike are insect-borne protozoan diseases that share overlapping endemic areas in sub-Saharan Africa. The causative agent for malaria has developed resistance ...