Now showing items 1-3 of 3
COVID-19 across Africa: epidemiologic heterogeneity and necessity of contextually relevant transmission models and intervention strategies
(American College of Physicians, 2020)
Coronavirus disease 2019 (COVID-19) has rapidly emerged as a global public health threat with epicenters in regions of China, parts of Europe, and larger urban centers across North America (1). By comparison, population-level ...
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes
Leishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but ...
Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies-activities against blood stage P. falciparum including PfKI3 C580Y mutants and liver stage P. berghei parasites
We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives ...