Now showing items 1-4 of 4
In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic absorption and highly variable ...
In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum
(Springer Nature, 2012)
The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the ...
Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology
Artemisinins have low aqueous solubility that results in poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate to low bioavailability. Artemisinin-based monotherapy ...
Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria
Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria. However, it has low solubility in water, a long elimination half-life (4 days), and is ...