Now showing items 1-5 of 5
Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisininetriazine hybrids and hybrid-dimers
A series of artemisininetriazine hybrids and hybrid-dimers were synthesized and their in vitro antimalarial activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) and the choroquine resistant (CQR) ...
Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin
In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and ...
Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids
The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought about in a two-step nucleophilic s ...
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ...
The evaluation of metal co-ordinating bis-thiosemicarbazones as potential anti-malarial agents
(Bentham Science, 2019)
Background: The emergence of resistance to the artemisinins which are the current mainstays for antimalarial chemotheraphy has created an environment where the development of new drugs acting in a mechanistally discrete ...