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Extracellular matrix biomarker, Fibulin–1 and Its association with Soluble uPAR in a Bi-ethnic South African population: the SAfrEIC study
(Elsevier, 2015)
Background
Fibulin-1 and soluble urokinase-type plasminogen activator receptor (suPAR) emerged as mediators in the development of sclerotic disease. SuPAR along with C-reactive protein (CRP) and albumin delineate ...
Growth differentiating factor-15 and its association with traditional cardiovascular risk factors: the African-PREDICT study.
(Elsevier, 2020)
Background and aims
Growth differentiating factor-15 (GDF-15) is a stress-induced and cardio-protective cytokine, reported to be influenced by a number of cardiovascular risk factors. In older adults, GDF-15 associated ...
Von Willebrand factor, its cleaving protease (ADAMTS13), and inflammation in young adults: the African-PREDICT study
(Elsevier, 2020)
Background
The role of inflammation in the early development of vascular dysfunction remains complex. Interleukin-6 (IL-6) and C-reactive protein (CRP) can cause an acute imbalance in the von Willebrand factor (vWF)-ADAMTS13 ...
Methylation vs. protein inflammatory biomarkers and their associations with cardiovascular function
(Frontiers Media, 2020)
DNA methylation data can be used to estimate proportions of leukocyte subsets retrospectively, when directly measured cell counts are unavailable. The methylation-derived neutrophil-to-lymphocyte and lymphocyte-to-monocyte ...
Distinct inflammatory mediator patterns in young black and white adults: the African-predict study
(Elsevier, 2020)
Objective
Inflammatory mediators have been implicated in the early stages of cardiovascular disease development, including hypertension. Since global reports reflect a higher hypertension prevalence in black than white ...
Inter-arm blood pressure difference and its relationship with retinal microvascular calibres in young individuals: the African-PREDICT study
(Elsevier Science Inc, 2016)
Background
Bilateral systolic blood pressure (SBP) differences > 10 mmHg is a common finding in clinical practice. Such BP differences in older individuals are associated with peripheral vascular disease, linked to ...