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Extracellular matrix biomarker, Fibulin–1 and Its association with Soluble uPAR in a Bi-ethnic South African population: the SAfrEIC study
(Elsevier, 2015)
Background
Fibulin-1 and soluble urokinase-type plasminogen activator receptor (suPAR) emerged as mediators in the development of sclerotic disease. SuPAR along with C-reactive protein (CRP) and albumin delineate ...
Ethnic differences regarding arterial stiffness of 6‐8‐year-old black and white boys
(Wolters Kluwer, 2017)
Objectives: Vascular deterioration is suggested to occur earlier in black than white populations, thereby increasing their risk for developing hypertension. To establish whether this is the case, we compared different ...
Cornell product relates to albuminuria in hypertensive black adults independently of blood pressure: the SABPA study
(Elsevier, 2015)
Evidence of the relationship between left ventricular hypertrophy and urinary albumin excretion is contradictory and limited in black adults in whom hypertensive heart disease is common. We aimed to investigate the ...
Left ventricular mass independently associates with 24-hour sodium excretion in young masked hypertensive adults: the African-PREDICT study
(Elsevier, 2019)
Background
Due to the known contribution of excess sodium intake on elevations in blood pressure, salt reduction regulations are being introduced in countries all over the world. To study the contribution of sodium intake ...
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
(Nature, 2020)
Hypertension is common in black populations and is known to be associated with low nitric oxide (NO) bioavailability. We compared plasma and urinary NO-related markers and plasma creatine kinase (CK) levels between young ...
Left ventricular mass and urinary metabolomics in young black and white adults: the African-PREDICT study
(Elsevier, 2020)
Background and aims
Increased left ventricular mass is an independent predictor for cardiovascular events, and shown to be higher in black than white populations. To gain a better understanding of early factors contributing ...
Adiposity and physical activity are related to heart rate variability: the African-PREDICT study
(Wiley, 2020)
Background
Physical inactivity contributes significantly to the development of obesity‐related cardiovascular disease. Adiposity may lead to reduced heart rate variability (HRV), whereas increased physical activity (PA) ...
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
(Springer, 2020)
Nitric oxide plays an important role in maintaining endothelial function, while increased oxidative stress may lead to nitric oxide inactivation and cardiovascular disease. If nitric oxide biosynthesis/bioavailability is ...
Growth differentiating factor-15 and its association with traditional cardiovascular risk factors: the African-PREDICT study.
(Elsevier, 2020)
Background and aims
Growth differentiating factor-15 (GDF-15) is a stress-induced and cardio-protective cytokine, reported to be influenced by a number of cardiovascular risk factors. In older adults, GDF-15 associated ...
Sex hormones associated with subclinical kidney damage and atherosclerosis in South African men: the SABPA study
(Kluwer, 2012)
Background: Hypertension and increased blood glucose are associated with subclinical kidney damage, atherosclerosis and with low testosterone values. Low testosterone in men is often accompanied by increased levels of ...