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The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat
(Wolters Kluwer, 2017)
Depression involves deficits in monoaminergic neurotransmission. Differential roles for α2A, B and C subtypes of the α2-adrenoceptor (AR) are evident, with selective α2C-AR antagonists purported to have antidepressant and ...
Is major depressive disorder a metabolic encephalopathy?
(Wiley, 2008)
Metabolic encephalopathy is an acute disturbance in cellular metabolism in the brain evoked by conditions of hypoxia, hypoglycaemia, oxidative stress and/or inflammation. It usually develops acutely or subacutely and is ...
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
(Elsevier, 2012)
Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result
possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine
oxidase A ...
Ketamine and rapidly acting antidepressants: breaking the speed of sound or light?
(Sage, 2018)
There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key ...
Ozone modulates the effects of imipramine on immobility in the forced swim test, and nonspecific parameters of hippocampal oxidative stress in the rat
(Springer, 2010)
Depression has been associated with oxidative stress. There is increased awareness of the role of environmental toxins in the development of mood disorders. Ozone, a pro-oxidant and environmental pollutant, has been noted ...
Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues
(Elsevier, 2010)
Dual action antidepressants have important therapeutic implications. Methylene blue (MB), a charged compound structurally related to tricyclic antidepressants, acts on both monoamine oxidase (MAO) and the nitric oxide ...
Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties
(Elsevier, 2014)
Aims: The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is
attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine
oxidase ...