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Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder
(Elsevier, 2008)
Stereotypy is an important manifestation of obsessive compulsive disorder (OCD). OCD involves disturbed serotonin and dopamine pathways, and demonstrates a selective response to serotonin reuptake inhibitors (SRI), with ...
Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to chronic escitalopram treatment and basal serotonin transporter (SERT) density
(Elsevier, 2013)
Obsessive-compulsive disorder (OCD) is characterized by recurrent thoughts and repetitive motor actions. Hyposerotonergic signalling in the cortico-striatal circuitry is believed to be central to the pathology of OCD, while ...
Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder
(Sage, 2016)
Obsessive–compulsive disorder (OCD) is a phenotypically heterogeneous condition characterised by time-consuming intrusive thoughts and/or
compulsions. Irrespective of the symptom type diagnosed, the severity of OCD is ...
Social behavior in deer mice as a novel interactive paradigm of relevance for obsessive-compulsive disorder (OCD)
(Taylor & Francis, 2017)
Greater obsessive-compulsive (OC) symptom severity may be associated with poor social adjustment. Rather than possessing deficits in social skill per se, OCD patients may be more socially isolative in the presence of normal ...
Translational medicine strategies in PTSD drug development
(Elsevier, 2019)
Once considered a normal response to an abnormal traumatic event, posttraumatic stress disorder (PTSD) has been reconceptualized in terms of unusual persistence of fear-conditioned responses. Selective serotonin reuptake ...
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
(Elsevier, 2009)
Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ...
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
(Elsevier, 2011)
The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ...
Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges
(Springer, 2018)
Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding ...
Of mice and marbles: novel perspectives on burying behavior as a screening test for psychiatric illness
(Springer, 2016)
Burying forms part of the normal behavioral routine of rodents, although its expression is species-specific. However, it has been suggested that aberrant burying behavior, of which marble-burying (MB) is an example, may ...
Differential effects of social isolation rearing on glutamate- and GABA-stimulated noradrenaline release in the rat prefrontal cortex and hippocampus
(Elsevier, 2020)
Social isolation rearing (SIR) provides an excellent model of early life adversity to investigate alterations in brain function. Few studies have investigated the effects of SIR on noradrenaline (NE) projections which arise ...