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The nature of relapse in schizophrenia
(BioMed Central, 2013)
Background: Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of important ...
Depression, cardiometabolic function and left ventricular hypertrophy in African men and women: the SABPA study
(Taylor & Francis, 2013)
Depressive symptoms are associated with an increased risk for developing cardiovascular diseases, driven by its link to the metabolic syndrome (MetS). This phenomenon, however, still needs to be investigated in the African ...
Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to chronic escitalopram treatment and basal serotonin transporter (SERT) density
(Elsevier, 2013)
Obsessive-compulsive disorder (OCD) is characterized by recurrent thoughts and repetitive motor actions. Hyposerotonergic signalling in the cortico-striatal circuitry is believed to be central to the pathology of OCD, while ...
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
(Elsevier, 2013)
Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory
abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine
release . N-acetyl cysteine ...
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)
Schizophrenia is causally associated with early-life
environmental stress, implicating oxidative stress in its pathophysiology.
N-acetyl cysteine (NAC), a glutathione precursor
and antioxidant, is emerging as a useful ...