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Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models
(Elsevier, 2012)
Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and have severe health
and socio-economic implications. Despite the availability of a number of treatment options there is still a
strong ...
Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study
(Kluwer, 2012)
Background: Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, the association between active ...
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
(Elsevier, 2012)
Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium
requires further study. Altered tryptophan metabolism has been described in schizophrenia,
possibly linked to ...
Neurochemical differences in two rat strains exposed to social isolation rearing
(Cambridge Univ Press, 2012)
Objective: Isolation rearing of rats provides a non-pharmacological method of inducing behavioural changes in rodents that resemble schizophrenia or depression. Nevertheless, results are variable within different strains. ...
Depressive symptoms and 24-hour ambulatory blood pressure in Africans: the SABPA study
(Hindawi, 2012)
Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association
between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) ...
Simulated systemic recurrent Mycoplasma infection in rats induces recurrent sickness responses without residual impairment in spatial learning and memory
(Elsevier, 2012)
In spite of their prevalence and importance, recurrent acute infections seldom have been investigated in the
laboratory. We set out to measure fever and sickness behaviour in simulated recurrent Mycoplasma infection;
Mycoplasma ...
Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression
(Cambridge, 2012)
Objective: Depression is suggested to involve disturbances in cholinergic as well as glutamatergic pathways, particularly the N-methyl-d-aspartate receptor-mediated release of nitric oxide (NO) and cyclic guanosine ...
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma
(Elsevier, 2012)
It is highly beneficial to monitor the activity of the kynurenine pathway in a large series of samples with high accuracy and reliability in a single experimental protocol. We have developed a rapid specific solid-phase ...
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
(Elsevier, 2012)
Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result
possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine
oxidase A ...
Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats
(Springer, 2012)
There are conflicting results from behavioural studies regarding whether the activation or inhibition of the cGMP-nitric oxide (NO) pathway induces anxiolytic-like behaviour. Sildenafil, an inhibitor of cGMP-selective ...