Search
Now showing items 1-10 of 250
In vitro skin permeation of sinigrin from its phytosome complex
(Wiley, 2016)
Objectives: Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently sinigrin and its phytosome formulations have been investigated for its wound healing actions, by our research group. The ...
Treatment modalities for acne
(MDPI, 2016)
Acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. It can have severe psychological effects and can leave the patient with severe skin scarring. There are four well-recognized ...
Traversing the skin barrier with nano-emulsions
(Bentham Science, 2016)
In recent years, colloidal delivery systems based on nano-emulsion are gaining popularity; being used for encapsulation and delivery of many drugs. Nano-emulsions are thermokinetically stable dispersion systems, which ...
Restricting the marketing of foods and non-alcoholic beverages to children in South Africa: are all nutrient profiling models the same?
(Cambridge Univ Press, 2016)
The WHO has called for governments to improve children’s food environment by implementing restrictions on the marketing of ‘unhealthy’ foods to children. Nutrient profiling (NP) models are used to define ‘unhealthy’ foods ...
Isolation and in vitro permeation of phenylpropylamino alkaloids from Khat (Catha edulis) across oral and intestinal mucosal tissues
(Elsevier, 2016)
Ethnopharmacological relevance: Khat, the leaves of Catha edulis, is used as a “natural amphetamine-like” stimulant in eastern and southern Africa, as well as in the Arabian Peninsula. Leaves are masticated to elicit a ...
In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration
(Taylor & Francis, 2016)
Introduction: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques ...
Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study
(Elsevier, 2016)
The striking impact that different preparation methods have on the characteristics of amorphous solidstate
forms has attracted considerable attention during the last two decades. The pursuit of more
extensive knowledge ...
Approximation-based integral versus differential isoconversional approaches to the evaluation of kinetic parameters from thermogravimetry: kinetic analysis of the dehydration of a pharmaceutical hydrate
(Springer, 2016)
The relative accuracies of approximation-based
integral versus differential isoconversional approaches for
‘actual’ E determination were investigated on experimental
dehydration data of roxithromycin monohydrate ...
The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol
(Elsevier, 2016)
Early studies suggest that selective α2C-adrenoceptor (AR)-antagonism has anti-psychotic-like and pro-cognitive properties. However, this has not been demonstrated in an animal model of schizophrenia with a neurodevelopmental ...
Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder
(Sage, 2016)
Obsessive–compulsive disorder (OCD) is a phenotypically heterogeneous condition characterised by time-consuming intrusive thoughts and/or
compulsions. Irrespective of the symptom type diagnosed, the severity of OCD is ...