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In-vitro transdermal penetration of cytarabine and its N4-alkylamide derivatives
(Wiley, 2010)
Objectives The aim of this study was to synthesise and determine the transdermal penetration of cytarabine alkylamide derivatives and assess the correlation of flux with physicochemical properties.
Methods The alkylamide ...
Artemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity
(Elsevier, 2010)
Novel artemisinin–quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90–110 °C). All compounds were obtained as the β-isomers and were tested against ...
Synthesis and in vitro human skin penetration of oligo- and polymeric ethylene glycol carbonates of zidovudine and stavudine
(Thieme, 2010)
In continuation of studies focusing on the transdermal delivery of antiretroviral (ARV) drugs, the skin permeation ability of synthesized homologous series of both oligomeric and polymeric ethylene glycol (PEG) carbonates ...
Synthesis and transdermal permeation of novel N4-methoxypoly(ethylene glycol) carbamates of cytarabine
(Taylor & Francis, 2010)
Background: Cytarabine is a deoxycytidine analogue commonly used in the treatment of hematological malignant diseases. Its clinical utility, however, is severely limited by its short plasma half-life because of the catabolic ...
Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines
(Thieme, 2010)
Series of 4-aminoquinolines bearing an amino side chain linked to the ferrocene moiety through an amide bond were synthesized and evaluated for their antimalarial activity against both chloro-quine-sensitive (D10, CQ-S) ...
Effects of oral administration of synthesized d-amides of eflornithine in the rat
(Thieme, 2010)
The purpose of this study was to synthesize a series of δ-amide derivatives of the antitrypanosomal drug eflornithine (2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride, DMFO, CAS 70052-12-9), to determine their ...
1-Bromo-2-(10 β-dihydroartemisinoxy)-ethane
(IUCr, 2010)
The title compound, C17H27BrO5, DEB, is a derivative of artemisinin which is used in malaria therapy. The OR-group at C12 is cis to the CH3-group at C11 and axially oriented on ring D which has a chair conformation. The ...