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Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
(Elsevier, 2013)
Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory
abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine
release . N-acetyl cysteine ...
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
(Elsevier, 2011)
Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR ...
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
(Elsevier, 2011)
The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ...