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A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses
(Wiley, 2014)
Communication between neurons is mediated by the
release of neurotransmitter-containing vesicles from
presynaptic terminals. Quantitative characterization of
synaptic vesicles can be highly valuable for understanding
...
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
(Wiley, 2013)
Depressive disorders and the treatment thereof have been associated
with a number of neuroplastic events, such as neurogenesis and synaptic remodeling
in discrete areas of the brain. The associations of these events in ...
Quantitative hippocampal structural changes following elctroconvulsive seizure treatment in a rat model of depression
(Wiley, 2012)
Objective: The pathophysiology of depression and the effects of antidepressant
treatment are hypothesized to be related to hippocampal structural
changes. This study aims to investigate the effect of electroconvulsive ...
Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus
(Elsevier, 2016)
Preclinical studies reveal that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). In the present study, we ...
Mitochondria are critical for BDNF-mediated synaptic and vascular plasticity of hippocampus following repeated electroconvulsive seizures
(Oxford Univ Press, 2018)
Background
Electroconvulsive therapy is a fast-acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections ...
A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment
(Oxford Univ Press, 2018)
Background
Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ...
Structural plasticity and molecular markers in hippocampus of male rats after acute stress
(Elsevier, 2020)
Stress plays a crucial role in the pathogenesis of psychiatric disorders and affects neuronal plasticity in different brain regions. We have previously found that acute foot-shock (FS) stress elicits fast and long-lasting ...