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Activities of 11-azaartemisinin and N-sulfonyl derivatives against asexual and transmissible malaria parasites
(Wiley, 2017)
Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clinical use—artemether and artesunate—induces quiescence in ring-stage parasites of ...
Activities of 11-azaartemisinin and N-sulfonyl derivatives against Neospora caninum and comparative cytotoxicities
(Wiley, 2017)
Neosporosis caused by the apicomplexan parasite Neospora caninum is an economically important disease that induces abortion in dairy and beef cattle. There are no vaccines or drugs available on the market for control or ...
Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides
(Elsevier, 2014)
A series of 4-aminoquinolinyl-chalcone amides 11–19 were synthesized through condensation of carboxylic
acid-functionalized chalcone with aminoquinolines, using 1,10-carbonyldiimidazole as coupling
agent. These compounds ...
Preliminary evaluation of artemisinin-cholesterol conjugates as potential drugs for the treatment of intractable forms of malaria and tuberculosis
(Wiley, 2018)
To evaluate the feasibility of developing drugs that may be active against both malaria and tuberculosis (TB) by using in part putative cholesterol transporters in the causative pathogens and through enhancement of passive ...
Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids
(Springer, 2020)
Infectious diseases such as tuberculosis and leishmaniasis are leading causes of human death. One of the major factors contributing to the poor control of these diseases is primarily the reduced effectiveness of the existing ...
Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues
(Elsevier, 2020)
The emergence of drug-resistant tuberculosis (DR-TB) as well as the requirement for long, expensive and toxic drug regimens impede efforts to control and eliminate TB. Therefore, there’s a need for effective and affordable ...
Synthesis and antimycobacterial activity of disubstituted benzyltriazoles
(Springer, 2019)
The increasing prevalence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the ...
Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
(Wiley, 2019)
Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ...
Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
(Nature, 2018)
The quinolone decoquinate is coadministered with feed for treatment of parasites which cause coccidiosis in poultry. However, from a drug-development perspective, the biological activity is often not adequately exploited ...
Recent progress in the development of anti-malarial quinolones
(BioMed Central, 2014)
Available anti-malarial tools have over the ten-year period prior to 2012 dramatically reduced the number of fatalities
due to malaria from one million to less than six-hundred and thirty thousand. Although fewer people ...