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The nature of relapse in schizophrenia
(BioMed Central, 2013)
Background: Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of important ...
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates
(Associação Brasileira de Psiquiatria (ABP), 2016)
Objective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important.
Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist
on genetic associations. ...
Prospective analysis of the medicine possession ratio of antidepressants in the private health sector of South Africa, 2006-2011
(Health & Medical Publishing Group, 2015)
Background: Major depressive disorder (MDD) is a disabling mental illness with high morbidity and mortality rates. Inadequate treatment
efficacy, unfavourable side-effect profiles and consequent shortfalls in compliance ...
The impact of HIV/AIDS on compliance with antidepressant treatment in major depressive disorder: a prospective study in a South African private healthcare cohort
(BioMed Central, 2015)
Background: MDD and HIV/AIDS have a high prevalence worldwide with severe consequences for patients. In
both conditions, compliance with treatment is key to successfully treat these disorders. In the current study, ...
Euphorbias of South Africa: two new phorbol esters from Euphorbia bothae
(South African Bureau for Scientific Publications, 2010)
Two known phorbol esters, 12-deoxyphorbol-13-isobutyrate-20-acetate (1) and 12-deoxyphorbol-13-(2-methylbutyrate)-20-acetate (2), and two new phorbol esters, 12-deoxyphorbol-13-isobutyrate-16-angelate-20-acetate (3) and ...
The therapeutic potential of Mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia
(Frontiers Media, 2019)
New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic ...
Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: role of corticosterone, oxytocin, and vasopressin
(Sage, 2019)
Background:
The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared ...
Studies on haloperidol and adjunctive alpha-mangostin or raw Garcinia Mangostana Linn pericarp on bio-behavioral markers in an immune-inflammatory model of schizophrenia in male rats
(Frontiers Media, 2020)
The nematicidal activity of crudely milled powders of stems, leaves, and bulbs of Cassia abbreviata, Cissus cactiformis, Euphorbia ingens, Ipomoea kituiensis, Synadenium cupulare, Senna petersiana, Urigenia sanguinea, ...
Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression
(Cambridge Univ Press, 2019)
Objectives:
Treatment-resistance to antidepressants is a major problem in the pharmacotherapy of major depressive disorder (MDD). Unfortunately, only a few animal models are suitable for studying treatment-resistant ...
Pathological consequences of drug abuse: implication of redox imbalance. Editorial
(Hindawi, 2019)
The onset, progression, and outcome of numerous pathological conditions, affecting different organs and systems, have
been widely reported to be significantly impacted by the
abuse of psychoactive compounds. In the last ...