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Ethnic-specific relationships between haemostatic and oxidative stress markers in black and white South Africans: the SABPA study
(Taylor & Francis, 2015)
Haemostatic– and oxidative stress markers are associated with increased cardiovascular risk. In the black population, evidence exists that both an imbalance in the haemostatic system and oxidative stress link with the ...
The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
(Springer, 2016)
Inadequate substrate availability and increased
nitric oxide synthase inhibitor levels attenuate nitric oxide
(NO) synthesis, whereas increased vascular oxidative
stress may lead to inactivation of NO. We compared
markers ...
The African prospective study on the early detection and identification of cardiovascular disease and hypertension (African-PREDICT): design, recruitment and initial examination
(Sage, 2019)
Background: Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an
increase. Although this might be attributed to poor healthcare and ineffective antihypertensive ...
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
(Nature, 2020)
Hypertension is common in black populations and is known to be associated with low nitric oxide (NO) bioavailability. We compared plasma and urinary NO-related markers and plasma creatine kinase (CK) levels between young ...
Left ventricular mass and urinary metabolomics in young black and white adults: the African-PREDICT study
(Elsevier, 2020)
Background and aims
Increased left ventricular mass is an independent predictor for cardiovascular events, and shown to be higher in black than white populations. To gain a better understanding of early factors contributing ...
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
(Springer, 2020)
Nitric oxide plays an important role in maintaining endothelial function, while increased oxidative stress may lead to nitric oxide inactivation and cardiovascular disease. If nitric oxide biosynthesis/bioavailability is ...
The relationship of blood pressure with uric acid and bilirubin in young lean and overweight/obese men and women: the African-PREDICT study
(Nature, 2020)
Mounting evidence supports the central role of oxidative stress and inflammation in obesity and the development of hypertension. However, most studies focusing on the non-enzymatic antioxidants, such as uric acid and ...
The association of measures of the micro- and macro-vasculature with selenium and GPx activity in a young bi-ethnic population: the African-PREDICT study
(Taylor & Francis, 2019)
Objective: Selenium plays an important physiological role as component for antioxidant selenoproteins such as glutathione peroxidase (GPx). Since oxidative stress contributes to hypertension development, it is likely that ...
Iron loading, alcohol and mortality: a prospective study
(Elsevier, 2019)
Background & aims
The relationship between total body iron and cardiovascular disease remains controversial and information absent in black sub-Saharan Africans in whom alcohol consumption tends to be high. The level of ...
Bioavailable IGF-1 is beneficially associated with biomarkers of endothelial function in young healthy adults: the African-PREDICT study
(Elsevier, 2018)
Low circulating levels of insulin-like growth factor-1 (IGF-1) are associated with endothelial dysfunction, subsequently leading to the development of cardiovascular disease.
Objective
To better understand the early ...