Browsing Faculty of Health Sciences by Subject "Stability"
Now showing items 1-10 of 10
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Amorphous sulfadoxine: a physical stability and crystallization kinetics study
(Springer Nature, 2016)Poor aqueous solubility of drugs and the improvement thereof has always been a challenge for the pharmaceutical industry.With this, one of the focuses of the pharmaceutical research scientist involves investigating ... -
The case for development of 11-aza-artemisinins for malaria
(Bentham Science, 2015)The current treatment regimens for uncomplicated malaria comprise an artemisinin in combination with another drug (ACT). However, the recent emergence of resistance to ACTs in South East Asia dramatically emphasizes the ... -
Characterization of polymorph transformations that decrease the stability of tablets containing the who essential drug mebendazole
(Elsevier, 2010)This study investigated the influence of moisture and heat on the stability of mebendazole polymorph C in tablets. The polymorphic forms of mebendazole display significant differences in solubility and therapeutic efficacy ... -
Formulation and evaluation of selected transmucosal dosage forms containing a double fixed-dose of acyclovir and ketoconazole
(Elsevier, 2018)Viral and fungal dermatological manifestations are often the first and only sign of HIV/AIDS. They are cosmetically disfiguring and threaten the quality of life, but can be treated by acyclovir and ketoconazole, correspondingly. ... -
Inulin suitable as reduced-kilojoule carrier for production of microencapsulated spray-dried green Cyclopia subternata (honeybush) extract
(Elsevier, 2017)Retention of phenolic compounds during spray-drying of an anti-diabetic C. subternata extract and physicochemical characteristics of spray-dried powders (pure extract and extract-carrier mixtures) were evaluated. Extract-carrier ... -
Physicochemical properties of amorphous roxithromycin prepared by quench cooling of the melt or desolvation of a chloroform solvate
(Springer, 2012)Roxithromycin is a poorly soluble antibacterial drug. The aim of this study was to prepare and characterize an amorphous form of roxithromycin. The amorphous form was prepared by desolvation of its chloroform solvate, and ... -
Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles
(Elsevier, 2014)A layer-by-layer (LbL) nanocoat (b25 nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method ... -
The stabilization of amorphous zopiclone in an amorphous solid dispersion
(Springer, 2015)Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid ... -
Topical delivery of acyclovir and ketoconazole
(Taylor & Francis, 2014)Context: Viral and fungal cutaneous manifestations are regularly encountered in immunocompromised HIV/AIDS individuals and can be treated by drugs such as acyclovir and ketoconazole, respectively. Objective: The aim of ... -
Topical delivery of Withania somnifera crude extracts in niosomes and solid lipid nanoparticles
(Medknow, 2017)Background: Withania somnifera is a medicinal plant native to India and is known to have anticancer properties. It has been investigated for its anti-melanoma properties, and since melanoma presents on the skin, it is ...