Browsing Faculty of Health Sciences by Subject "Prodrug"
Now showing items 1-3 of 3
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The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
(MDPI, 2017)l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ... -
Prodrug strategies for enhancing the percutaneous absorption of drugs
(MDPI, 2014)The transdermal application of drugs has attracted increasing interest over the last decade or so, due to the advantages it offers, compared to other delivery methods. The development of an efficient means of transdermal ... -
Synthesis of methodxypoly (ethylene glycol) carbonate prodrugs of zidovudine and penetration through human skin in vitro
(Wiley, 2009)The aim of this study was to synthesise a series of novel methoxypoly(ethylene glycol) carbonate prodrugs of the antiretroviral drug zidovudine (azidothymidine, AZT) in an attempt to enhance the physicochemical properties ...