Browsing Faculty of Health Sciences by Subject "Permeation enhancer"

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    • Combining chemical permeation enhancers for synergistic effects 

      Du Toit, Trizel; Malan, Maides M.; Lemmer, Hendrik J.R.; Gouws, Chrisna; Aucamp, Marique E.; Breytenbach, Wilma J.; Hamman, Josias H. (Springer, 2016)
      Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study ...

    • Topical delivery of 5-fluorouracil from Pheroid™ formulations and the in vitro efficacy against human melanoma 

      Chinembiri, Tawona N.; Gerber, Minja; Du Plessis, Lissinda; Du Preez, Jan; Du Plessis, Jeanetta (Springer, 2015)
      Drug delivery vehicles can influence the topical delivery and the efficacy of an active pharmaceutical ingredient (API). In this study the influence of Pheroid™ technology, which is a unique colloidal drug delivery system, ...