Browsing Faculty of Health Sciences by Subject "Epigenetics"
Now showing items 1-4 of 4
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Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ... -
Methylation vs. protein inflammatory biomarkers and their associations with cardiovascular function
(Frontiers Media, 2020)DNA methylation data can be used to estimate proportions of leukocyte subsets retrospectively, when directly measured cell counts are unavailable. The methylation-derived neutrophil-to-lymphocyte and lymphocyte-to-monocyte ... -
MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro
(Oxford Univ Press, 2016)Background: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the ... -
Neuroprogression in schizophrenia: pathways underpinning clinical staging and therapeutic corollaries
(Sage, 2014)Objective: Whilst dopaminergic dysfunction remains a necessary component involved in the pathogenesis of schizophrenia, our current pharmacological armoury of dopamine antagonists does little to control the negative ...