Browsing Faculty of Health Sciences by Subject "Apoptosis"
Now showing items 1-6 of 6
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Characterization of the cell-free DNA released by cultured cancer cells
(Elsevier, 2016)The most prominent factor that delays the translation of cell-free DNA (cfDNA) analyses to clinical practice is the lack of knowledge regarding its origin and composition. The elucidation of the former is complicated by ... -
An enquiry concerning the characteristics of cell-free DNA released by cultured cancer cells
(Springer, 2016)Non-invasive screening that utilizes cell-free DNA (cfDNA) offers remarkable potential as a method for the early detection of genetic disorders and a wide variety of cancers. Unfortunately, one of the most prominent elements ... -
Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro
(Elsevier, 2017)In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ... -
In vitro evaluation of the cytotoxic and apoptogenic properties of aloe whole leaf and gel materials
(Taylor & Francis, 2014)Aloe gel and whole-leaf materials have shown biological effects with potential therapeutic applications, and recently, their drug-absorption enhancement properties have been discovered. It is important to establish a ... -
Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents
(Elsevier, 2014)The aim of this study was to design drug-like molecules with multiple neuroprotective mechanisms which would ultimately inhibit N-methyl-D-aspartate (NMDA) receptors, block L-type voltage gated calcium channels (VGCC) ... -
Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids
(Elsevier, 2014)During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and the in vitro for antimalarial activity against both the chloroquine sensitive but also gametocytocidal strain (NF54), and ...