Browsing Faculty of Health Sciences by Author "10062718 - Huisman, Hugo Willem"
Now showing items 1-20 of 79
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
Adipokines and cardiometabolic function: how are they interlinked?
Schutte, Aletta Elisabeth; Huisman, Hugo Willem; Schutte, Rudolph; Van Rooyen, Johannes Marthinus; Malan, Leoné; Fourie, Catharina Maria Theresia; Malan, Nicolaas Theodor (Elsevier, 2010)Objective Adipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction. Most studies focus on a single adipokine. We therefore investigated the independent relationships of leptin, ... -
The African prospective study on the early detection and identification of cardiovascular disease and hypertension (African-PREDICT): design, recruitment and initial examination
Schutte, Aletta E.; Uys, Aletta S.; Burger, Adele; Mels, Catharina M.C.; Kruger, Ruan; Smith, Wayne; Fourie, Carla M.T.; Botha, Shani; Lammertyn, Leandi; Van Rooyen, Johannes M.; Gafane-Matemane, Lebo F.; Mokwatsi, Gontse G.; Breet, Yolandi; Kruger, H. Salome; Van Zyl, Tertia; Pieters, Marlien; Zandberg, Lizelle; Louw, Roan; Moss, Sarah J.; Huisman, Hugo W. (Sage, 2019)Background: Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive ... -
Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study
Schutte, R.; Huisman, H.W,; Malan, L.; Van Rooyen, J.M.; Smith, W. (Elsevier, 2013)Background: Vascular calcification is believed to be due to the conversion of vascular smooth muscle cells into osteoblast-like cells and is associated with mortality. Since hypertension and related mortality in Africans ... -
Antioxidant enzyme activity is associated with blood pressure and carotid intima media thickness in black men and women: the SABPA study
Van Zyl, Caitlynd; Huisman, Hugo W.; Mels, Catharina M.C. (Elsevier, 2016)In the urbanized black population of South Africa, oxidative stress may play a crucial role in the development of hypertension. Since oxidative stress may result from impaired antioxidant capacity we aimed to investigate ... -
Are behavioural risk factors to be blamed for the conversion from optimal blood pressure to hypertensive status in black South Africans? A 5-year prospective study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Carla M.T. (Oxford University Press, 2012)Background Longitudinal cohort studies in sub-Saharan Africa are urgently needed to understand cardiovascular disease development. We, therefore, explored health behaviours and conventional risk factors of African individuals ... -
Arterial stiffness profiles: investigating various sections of the arterial tree of African and caucasian people
Huisman, Hugo Willem; Malan, Nicolaas Theodor; Schutte, Aletta Elisabeth; Schutte, Rudolph; Van Rooyen, Johannes Marthinus; Malan, Leoné; Reimann, Manja (Informa healthcare, 2011)In Africans, arterial stiffness progression seems more pronounced compared to Caucasians. We compared the arterial stiffness profiles of different age groups and focused on muscular arteries and two more central arterial ... -
Arterial stiffness, ambulatory blood pressure and low-grade albuminuria in non-diabetic African and caucasian men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Glyn, Matthew C.P.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Nature Publishing Group, 2011)Recent evidence suggests that low-grade urinary albumin excretion is a marker of early general attenuation of vascular function, but studies are limited to Caucasian population groups. We compared low-grade urinary albumin ... -
Assessing tobacco use in an African population: serum and urine cotinine cut-offs from South Africa
Ware, Lisa J.; Kruger, Ruan; Breet, Yolandi; Van Rooyen, Johannes; Huisman, Hugo; Botha, Shani; Uys, Aletta S.; Schutte, Aletta E. (Elsevier, 2019)Background Cotinine, a nicotine metabolite, is used to measure tobacco use and exposure, but recommended cut-offs to differentiate tobacco users from those exposed through the environment range from 3 to 58 ng/ml in serum, ... -
The association of 25(OH)D with blood pressure, pulse pressure and carotid–radial pulse wave velocity in African women
Kruger, Iolanthé M.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Malan, Nicolaas T.; Fourie, Carla M.T.; Kruger, Annamarie (Public Library of Science, 2013)High susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased ... -
The association of endothelin-1 with markers of oxidative stress in a biethnic South African cohort: the SABPA study
Du Plooy, Christine Susara; Mels, Catharina Martha Cornelia; Huisman, Hugo Willem; Kruger, Ruan (Springer Nature, 2017)Both endothelin-1 and oxidative stress have important roles in the development of cardiovascular diseases such as hypertension and atherosclerosis. Limited information is available on the interaction between oxidative ... -
The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women
Huisman, Hugo W.; Schutte, Aletta E.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Fourie, Catharina M.T.; Malan, Nicolaas T. (Informa Healthcare, 2009)The literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Associations of cholesterol and glucose with cardiovascular dysfunction in black Africans: the SABPA study
Lammertyn, Leandi; Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Informa healthcare, 2011)The aim was to determine whether blood glucose or cholesterol is the more prominent contributor to cardiovascular dysfunction in 101 African men and 99 African women. We measured ambulatory daytime blood pressure (BP), ... -
Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study
Mels, Catharina M.C.; Schutte, A.E.; Huisman, H.W.; Smith, W.; Kruger, R.; Van Rooyen, J.M.; Malan, N.T.; Malan, L. (Springer, 2017)The relationship of both asymmetric (ADMA) and symmetric (SDMA) dimethylarginine with carotid wall thickness is inconclusive especially among black populations. We aimed to compare carotid intima media thickness (cIMT) and ... -
Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: a five-year prospective study
Schutte, Aletta E.; Conti, Elena; Mels, Catharina M.C.; Smith, Wayne; Kruger, Ruan; Botha, Shani; Huisman, Hugo W. (Sage Publications Ltd, 2016)Background: Inconsistent findings are reported on whether insulin-like growth factor-1 (IGF-1) is protective or harmful in predicting hypertension, carotid wall thickness and mortality. We determined the five-year ... -
Blood glutathione and subclinical atherosclerosis in African men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Szabolcs, Péter; Fourie, Carla M.T.; Van der Westhuizen, Francois H.; Louw, Roan; Botha, Cindy A.; Malan, Leoné (Oxford Univ Press, 2009)Background: Sub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities ... -
Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA study
Schutte, Aletta E.; Schutte, Rudolph; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Catharina M.T.; Malan, Nicolaas T.; Malan, Leoné (Nature Publishing Group, 2011)The prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention. The need for early markers of cardiovascular dysfunction is imperative in black South Africans who have a significant ... -
Cardiometabolic markers to identify cardiovascular disease risk in HIV-infected black South Africans
Van Rooyen, J.M.; Fourie, C.M.T.; Steyn, H.S.; Koekemoer, G.; Huisman, H.W.; Schutte, R.; Malan, L.; Glyn, M.; Smith, W.; Mels, C.; Schutte, A.E. (2014)Background. The prevalence of HIV is the highest in sub-Saharan Africa; South Africa (SA) is one of the most affected countries with the highest number of adults living with HIV infection in the world. Besides ... -
Cardiovascular function is not associated with creatine kinase activity in a black African population: the SABPA study
Mels, Catharina M.C.; Van Zyl, Caitlynd; Huisman, Hugo W. (Biomed Central Ltd, 2016)Background: Higher creatine kinase (CK) activity is associated with the development of cardiovascular disease in black African populations. We compared CK activity and investigated associations of blood pressure with CK ...