Browsing Faculty of Health Sciences by Subject "Xanthine"

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8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity

Carrageta, David F.; Van der Walt, Mietha M.; Terre'Blanche, Gisella; Dias, Tânia R.; Jarak, Ivana (Elsevier, 2018)

Caffeine is one of the most worldwide consumed methylxanthines. It is well-known for its thermogenic and cell metabolism modulating effects. Based on methylxanthines' chemical structure, 8-(3-phenylpropyl)-1,3,7-triethylxanthine ...
The adenosine A2A antagonistic properties of selected C8-substituted xanthines

Van der Walt, Mietha M.; Terre’Blanche, Gisella; Petzer, Anél; Lourens, Anna C.U.; Petzer, Jacobus P. (Elsevier, 2013)

The adenosine A2A receptor is considered to be an important target for the development of new therapies for Parkinson’s disease. Several antagonists of the A2A receptor have entered clinical trials for this purpose and ...