Browsing Faculty of Health Sciences by Subject "Synapse"

Now showing items 1-2 of 2

A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment

Chen, Fenghua; Wegener, Gregers; Danladi, Jibrin; Ardalan, Maryam; Elfving, Betina (Oxford Univ Press, 2018)

Background Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ...
Mitochondria are critical for BDNF-mediated synaptic and vascular plasticity of hippocampus following repeated electroconvulsive seizures

Chen, Fenghua; Ardalan, Maryam; Elfving, Betina; Wegener, Gregers; Madsen, Torsten M. (Oxford Univ Press, 2018)

Background Electroconvulsive therapy is a fast-acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections ...