Browsing Faculty of Health Sciences by Subject "Stavudine"

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Synthesis and in vitro human skin penetration of oligo- and polymeric ethylene glycol carbonates of zidovudine and stavudine

N'Da, David D.; Breytenbach, Jaco C.; Breytenbach, J. Wilhelmina (Thieme, 2010)

In continuation of studies focusing on the transdermal delivery of antiretroviral (ARV) drugs, the skin permeation ability of synthesized homologous series of both oligomeric and polymeric ethylene glycol (PEG) carbonates ...
Synthesis and in vitro transdermal penetration of methoxypoly(ethylene glycol) carbonate derivatives of stavudine (3TC)

N'Da, David D.; Breytenbach, Jaco C.; Legoabe, Lesetja J.; Breytenbach, J. Wilma (Bentham Science, 2009)

The objective of this study was to synthesize derivatives of the anti-HIV drug stavudine (d4T) with more favourable physicochemical properties for transdermal delivery in an effort to increase transdermal penetration of ...
Synthesis and transdermal penetration of stavudine-5'-esters.

Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2010)

The aim of this study was to investigate the effects of different ester groups in position 5’ of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...