Browsing Faculty of Health Sciences by Subject "Sleeping sickness"

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Anti-trypanosomal and antimalarial properties of tetralone derivatives and structurally related benzocycloalkanones

Beteck, Richard M.; Legoabe, Lesetja J.; Isaacs, Michelle; Khanye, Setshaba D.; Laming, Dustin (MDPI, 2019)

Background and objectives: Sleeping sickness and malaria alike are insect-borne protozoan diseases that share overlapping endemic areas in sub-Saharan Africa. The causative agent for malaria has developed resistance ...
Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma

Cloete, Theunis T.; N'Da, David D.; Breytenbach, Jaco C.; Johansson, Carl C.; Kumar Vodnala, Suman (Thieme, 2011)

The aim of this study was to synthesize a series of mono-, di- and trisubstituted derivatives of the human African trypanosomiasis drug eflornithine (alpha-difluoromethylornithine, DMFO, CAS 70052-12-9) to determine their ...