Browsing Faculty of Health Sciences by Subject "Selectivity"

Now showing items 1-5 of 5

    • Antiplasmodial activity and cytotoxicity of 10β-aminoquinolinylethylethers of artemisinin 

      N'Da, D.D.; Lombard, M.C.; Clark, J.A.; Connelly, M.C.; Matheny, A.L. (Thieme, 2013)
      Each year roughly 800 000 people die of malaria, with 95% being African children. The shortcomings of the current drugs and the emergence of P. falciparum resistance to the artemisinin class of compounds warrant the search ...

    • Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives 

      Meiring, Letitia; Petzer, Jacobus P.; Petzer, Anél (Elsevier, 2013)
      In the present study, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3,4-dihydro-2(1H)- quinolinone derivatives ...

    • Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives 

      Okaecwe, Thokozile; Swanepoel, Abraham J.; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)
      A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...

    • Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues 

      Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2011)
      Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform ...

    • Monoamine oxidase inhibition by selected anilide derivatives 

      Legoabe, Lesetja; Kruger, Johann; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2011)
      A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were ...