Browsing Faculty of Health Sciences by Subject "Promastigote"

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Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide

Kannigadu, Christina; Aucamp, Janine; N'Da, David D. (Wiley, 2020)

Leishmaniasis is a vector‐borne parasitic disease that mostly affects populations in tropical and subtropical countries. There is currently no vaccine to protect against and only a handful of drugs are available to treat ...
Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives

Prinsloo, Izak F.; Zuma, Nonkululeko H.; Aucamp, Janine; N'Da, David D. (Wiley, 2020)

Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically ...
Synthesis and in vitro Leishmania promastigote growth inhibition efficacy of novel 4(3H)-quinazolinone derivatives

Ralph, Greg L.; Zuma, Nonkululeko H.; Aucamp, Janine; N'Da, David D. (ARKAT USA, 2020)

Molecular hybridization is an increasingly important strategy in rational drug design and development. A series of novel quinazolinone-triazole hybrids have been synthesized and their antileishmanial activity investigat ...