Browsing Faculty of Health Sciences by Subject "Preclinical research"

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Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats

Möller, Marisa; Fourie, Jaco; Harvey, Brian Herbert (Nature, 2018)

Efavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following sub-acute exposure ...