Browsing Faculty of Health Sciences by Subject "Physicochemical properties"
Now showing items 1-4 of 4
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The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
(MDPI, 2017)l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ... -
Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P
(Govi-Verlag, 2016)Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ... -
Inulin suitable as reduced-kilojoule carrier for production of microencapsulated spray-dried green Cyclopia subternata (honeybush) extract
(Elsevier, 2017)Retention of phenolic compounds during spray-drying of an anti-diabetic C. subternata extract and physicochemical characteristics of spray-dried powders (pure extract and extract-carrier mixtures) were evaluated. Extract-carrier ... -
Synthesis and transdermal permeation of novel N4-methoxypoly(ethylene glycol) carbamates of cytarabine
(Taylor & Francis, 2010)Background: Cytarabine is a deoxycytidine analogue commonly used in the treatment of hematological malignant diseases. Its clinical utility, however, is severely limited by its short plasma half-life because of the catabolic ...
