Browsing Faculty of Health Sciences by Subject "Neurodegenerative disorders"

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The monoamine oxidase inhibition properties of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one derivatives

Marais, Lereze; Petzer, Anél; Petzer, Jacobus P.; Legoabe, Lesetja J. (Springer, 2020)

Quinazolinone compounds are of interest in medicinal chemistry since they display a wide range of biological properties. In the present study, a series of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one ...
Multifunctional enzyme inhibition for neuroprotection: a focus on MAO, NOS, and AChE inhibitors

Joubert, Jacques; Petzer, Jacobus P.; Repsold, Benjamin P.; Prins, Louis H.A.; Malan, Sarel F. (Elsevier, 2015)

Neurodegenerative disorders are known to be multifactorial in nature and current research focus has moved from a ‘one-drug-one-target approach’ to that of drugs which are able to act at various relevant biological targets. ...
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies

De Monte, Celeste; Petzer, Anél; N'Da, Clarina I.; Petzer, Jacobus P.; Carradori, Simone (Elsevier, 2014)

Although there are clinical trials and in vivo studies in literature regarding the anxiolytic and antidepressant activities of the components of Crocus sativus L., their effects on the human monoamine oxidases (hMAO-A ...