Browsing Faculty of Health Sciences by Subject "Neurodegeneration"

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S-nitrosylation and attenuation of excessive calcium flux by pentacycloundecane derivatives

Lemmer, Hendrik J.R.; Joubert, Jacques; Van Dyk, Sandra; Van der Westhuizen, Francois H.; Malan, Sarel F. (Bentham Science, 2012)

A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel and N-methyl-D-aspartate receptor modulating activity. The synthesised compounds were ...
Synthesis and biological evaluation of pentacycloundecylamines and triquinylamines as voltage-gated calcium channel blockers

Young, Lois-May; Domingo, Olwen C.; Malan, Sarel F.; Geldenhuys, Werner J.; Van der Schyf, Cornelis J. (Wiley, 2016)

Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as ...