Browsing Faculty of Health Sciences by Subject "Isoniazid"

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Development and evaluation of a reconstitutable dry suspension containing isoniazid for flexible pediatric dosing

Adeleke, Oluwatoyin A.; Hayeshi, Rose K.; Davids, Hajierah (MDPI, 2020)

Tuberculosis (TB) is a major cause of childhood death. Despite the startling statistics, it is neglected globally as evidenced by treatment and clinical care schemes, mostly extrapolated from studies in adults. The objective ...
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Booysen, L.L.I.J.; Kotzé, A.F.; Du Plessis, L.H.; Kalombo, L.; Brooks, E. (Elsevier, 2013)

Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small ...
Permeation of PLGA nanoparticles across different in vitro models

Nkabinde, Lindiwe A.; Hamman, Josias H.; Shoba-Zikhali, Lungile N.N.; Semete-Makokotlela, Boitumelo; Kalombo, Lonji (Bentham Science, 2012)

Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance ...