Browsing Faculty of Health Sciences by Subject "Hardness"

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Development of multiple-unit pellet system tablets by employing the SeDeM expert diagram system. I. Pellets with different sizes

Hamman, Hannlie; Hamman, Josias; Wessels, Anita; Scholtz, Jacques; Steenekamp, Jan Harm (Taylor & Francis, 2017)

Multiple-unit pellet systems (MUPS) provide several pharmacokinetic and pharmacodynamic advantages over single-unit dosage forms, however, compression of pellets into MUPS tablets present certain challenges. Although the ...
Development of multiple-unit pellet system tablets by employing the SeDeM expert diagram system. II. Pellets containing different active pharmaceutical ingredients

Hamman, Hannlie; Hamman, Josias; Wessels, Anita; Scholtz, Jacques; Steenekamp, Jan (Taylor & Francis, 2019)

The SeDeM Expert Diagram System (SeDeM EDS) was originally developed to provide information about the suitability of powders to produce direct compressible tablets. Multiple-unit pellet systems (MUPS) are dosage forms ...