Browsing Faculty of Health Sciences by Subject "Fumarate"

Now showing items 1-1 of 1

Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro

Wentzel, Johannes F.; Lewies, Angélique; Bronkhorst, Abel J.; Van Dyk, Etresia; Du Plessis, Lissinda H.; Pretorius, Piet J. (Elsevier, 2017)

In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ...