Browsing Faculty of Health Sciences by Subject "DNA methylation"

Now showing items 1-3 of 3

Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene

Wei, Ya Bin; Wegener, Gregers; Melas, Philippe A.; Mathé, Aleksander A.; Lavebratt, Catharina (Oxford Univ Press, 2015)

Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ...
Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro

Wentzel, Johannes F.; Lewies, Angélique; Bronkhorst, Abel J.; Van Dyk, Etresia; Du Plessis, Lissinda H.; Pretorius, Piet J. (Elsevier, 2017)

In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ...
Leveraging the urban-rural divide for epigenetic research

Cronjé, Héléne T.; Nienaber-Rousseau, Cornelie; Pieters, Marlien; Elliott, Hannah R. (Future Medicine, 2020)

Urbanization coincides with a complex change in environmental exposure and a rapid increase in noncommunicable diseases (NCDs). Epigenetics, including DNA methylation (DNAm), is thought to mediate part of the association ...